http://repository.uhamka.ac.id/id/eprint/17521/
Studi Kerapatan Kerang Kima (Tridacnidae) Di Pulau Pramuka dan Pulau Belanda,
Kepulauan Seribu, DKI Jakarta
Maryanti, Setyaningsih
http://repository.uhamka.ac.id/id/eprint/17521/1/Studi%20Kerapatan%20kerang%20Kima-02072022.pdf
http://repository.uhamka.ac.id/id/eprint/17523/
EVALUASI IMPLEMENTASI KURIKULUM TINGKAT SATUAN PENDIDIKAN (KTSP) 2013 PADA PELAJARAN AL-ISLAM DI SD MUHAMMADIYAH 5 JAKARTA
Lismawati, Lismawati
http://repository.uhamka.ac.id/id/eprint/17523/1/ANALISIS%20BUTIR%20SOAL%20ISMUBA%20%28AL-ISLAM%2C%20KEMUHAMMADIYAHAN%20KELAS%20IV%20SD%20MUHAMMADIYAH%205.pdf
http://repository.uhamka.ac.id/id/eprint/17279/
INKLUSI HOTS DALAM TEAM GAMES TOURNAMANENT
Budhi, Akbar
http://repository.uhamka.ac.id/id/eprint/17279/1/e-book_Buku%20Referensi%20Inklusi%20HOTS%20dalam%20Team%20Games%20Tournament_%20uu%2028%202014_fixx_compressed.pdf
http://repository.uhamka.ac.id/id/eprint/17301/
Program komputer CASTLE MATH
Ishaq, Nuriadin
http://repository.uhamka.ac.id/id/eprint/17301/1/Program%20komputer%20CASTLE%20MATH.pdf
http://repository.uhamka.ac.id/id/eprint/17280/
Rev-erb agonist improves adverse cardiac
remodeling and survival in myocardial
infarction through an anti-inflammatory
mechanism
Endin Nokik Stujanna, Endin
As a leading cause of death and an increasing health burden worldwide,
myocardial infarction (MI) remains one of the most important clinical
entities. After the onset of MI, the left ventricle (LV) undergoes a
continuum of molecular, cellular, and extracellular responses that result in
LV wall thinning, dilatation, and dysfunction (Thygesen et al., 2012). The
cardiac healing and remodeling process after MI can be divided into four
phases: the death of cardiomyocytes, acute inflammation, the formation of
granulation tissue, and scar formation (Figure 1). Acute inflammation
usually occurs just after the onset of myocardial infarction. During this
phase, neutrophils and monocytes are recruited into necrotic tissue, and
they release inflammatory cytokines and matrix metalloproteinase (MMP)
(Liehn et al., 2011). Inflammatory cell infiltration and MMP production
play important roles in the degradation of necrotic debris and the
subsequent scar formation. However, excess inflammatory response and
MMP overproduction are likely to induce adverse cardiac remodeling,
leading to left ventricular dilatation, dysfunction, and cardiac rupture
(Frangogiannis, 2015; Matsui et al., 2010). Despite the significant progress
made on therapeutic strategies for MI in last few decades, mortality and
morbidity remain high, and adverse cardiac remodeling after MI remains a
critical issue to be solved. Therefore, continuous improvement in
medications for the disease is still a major concern in global medical
research.
Nuclear receptors (NRs) are members of a large superfamily and
widely considered as ligand-activated transcriptional factors. These were
originally found within cells that are responsible for sensing steroid and
thyroid hormones and certain other molecules, and work with other
proteins to regulate the expression of specific genes, thereby controlling the
development, homeostasis, and metabolism of the organism (Chambon,
2005; Evans, 2005). Nuclear receptors represent one of the most important
targets for therapeutic drug development, and many compounds targeted
for nuclear receptors have already been developed as marketable drugs, e.g.
peroxisome proliferator-activated receptor α and γ activators.
Rev-erb belongs to a nuclear receptor superfamily, and contains two
subgroups, Rev-erb α (NR1D1) and β (NR1D2). Rev-erb α is highly
expressed in the liver, skeletal muscle, adipose tissue, heart and brain,
participating in the development and circadian regulation of these tissues.
(Solt et al., 2012). Rev-erb β displays a similar structure and has been
implicated in the control of lipid and glucose metabolism and circadian
rhythm, collaborating extensively with Rev-erb α (Bugge et al., 2012).
Heme was identified as a physiological ligand for Rev-erb receptor, which
regulates their transcriptional activity (Figure 2). Moreover, Rev-erb α
displays a hydrophobic interface that binds the corepressor N-CoR, making
it a potent transcriptional repressor (Solt et al., 2012; Woldt et al., 2013).
Previous studies reported Rev-erb α regulated mitochondrial biogenesis in
loss- and gain-of-function settings. Rev-erb α deficiency in skeletal muscle
resulted in reduced mitochondrial content and ATP production through
deactivating AMPK-SIRT1–PGC1 signaling pathway (Woldt et al., 2103).
Recently, SR9009 and SR9011 were developed as synthetic Rev-erb
agonists, which facilitates Rev-erb α to recruit its corepressor NCoR and
repress downstream targets (Solt et al., 2012). From the results of the
previous studies using agonists, it has been identified that the nuclear
receptor Rev-erb α plays a pivotal role in the modulation of skeletal muscle
oxidative capacity by regulating mitochondrial biogenesis and autophagy,
leading to increasing in exercise capacity (Woldt et al., 2013). Moreover,
long-term treatment with SR9009 was shown to reduce atherosclerotic
plaque by decreasing the ratio of proinflammatory M1 macrophages to
anti-inflammatory M2 macrophages in low-density lipoprotein (LDL)
receptor-deficient mice fed a Western diet (Sitaula et al., 2015). Therefore,
Rev-erb is expected to be a promising therapeutic target for metabolic
syndrome and atherosclerotic disease. However, little is known about the
Rev-erb agonist effect on the progression of MI and heart failure
http://repository.uhamka.ac.id/id/eprint/17280/1/disertation%20Endin%20%281%29.pdf
http://repository.uhamka.ac.id/id/eprint/17302/
Program Komputer MATH MOBILE LEARNING BANGUN DATAR
Ishaq, Nuriadin
http://repository.uhamka.ac.id/id/eprint/17302/2/Program%20Komputer%20MATH%20MOBILE%20LEARNING%20BANGUN%20DATAR.pdf
http://repository.uhamka.ac.id/id/eprint/17281/
Rev-erb agonist improvest adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism
Endin Nokik Stujanna, Endin
http://repository.uhamka.ac.id/id/eprint/17281/1/reverb%20cek%20similiarity.pdf
http://repository.uhamka.ac.id/id/eprint/17449/
BUDAYA KERJA DOSEN UHAMKA STUDI KORELASIONAL ANTARA PRODUKTIVITAS DAN KOMPENSASI KERJA DENGAN BUDAYA KERJA DOSEN UHAMKA
Heri, Totong
Penelitian ini bertujuan untuk mempelajari hubungan antara produktivitas dan kompensasi kerja dengan budaya kerja Dosen, baik secara sendiri-sendiri maupun bersama-sama.
Penelitian dilaksanakan pada Universitas Prof. DR. HAMKA, dengan metode survey. Responden penelitian Dosen berjumlah 175 orang (20 orang untuk uji coba dan 155 orang untuk penelitian), dipilih berdasarkan teknik acak sederhana (simple random sampling). Instrumen menggunakan angket Budaya Kerja Dosen sebagai variabel terikat, sedangkan instrument angket Produktivitas dan Kompensasi kerja sebagai variabel bebas.
Instrumen angket Budaya Kerja Dosen, Produktivitas, dan Kompensasi Kerja divalidasi dengan rumus korelasi product moment, sedangkan relibilitas diukur dengan rumus Alpha Cronbach.
Analisis data menggunakan teknik korelasi dan regresi (sederhana/jamak).
Dari hasil penelitian ditemukan bahwa: (1) terdapat hubungan positif antara Produktivitas dengan Budaya Kerja Dosen, di mana koefisien korelasi ry1 = 0,406; pada taraf signifikansi 0,05 dan persamaan korelasi Y = 151. 092 + 1.003 X1; (2) terdapat hubungan positif antara Kompensasi Kerja dengan Budaya Kerja Dosen, dimana koefisien korelasi ry2 = 0,284 pada taraf signifikansi 0,05 dan persamaan korelasi Y = 151. 092 + 0,992 X2; dan (3) terdapat hubungan positif antara Produktivitas dan Kompensasi Kerja secara bersama-sama dengan Budaya Kerja Dosen, dimana koefisien korelasi jamak Ry.12 = 0,808; pada taraf signifikansi 0,05 dan persamaan regresi jamak Y = -151.092 + 1.003X1 + 0,992X2.
Berdasarkan hasil temuan tersebut, disimpulkan bahwa Budaya Kerja Dosen dapat meningkat apabila Produktivitas dan Kompensasi Kerja juga meningkat. Upaya peningkatan produktivitas dilakukan melalui pelatihan, pendidikan, dan seminar. Sedangkan upaya peningkatan Kompensasi Kerja dilakukan melalui pemberian penghargaan, pengakuan, dan jaminan sosial.
http://repository.uhamka.ac.id/id/eprint/17449/1/TESIS_TOTONG%20HERI.pdf
http://repository.uhamka.ac.id/id/eprint/17282/
Evaluation of morphology and viability of spheroid derived from Insulin-GLase cell
line: A model system to understand Type 2 Diabetes Mellitus
Sri Suciati Ningsih, Suci
Type 2 Diabetes Mellitus (T2DM) is one of the major health issues in the world. The cellular mechanism of T2DM is still not fully understood.
It could be studied by using spheroid three-dimensional (3D) culture which is considered representative of the in vivo conditions. Several types
of pancreatic β cell lines have been used, one of which is the insulin-GLase (iGL) cell line. This study aims to evaluate the effect of cell density
and incubation time on spheroid morphology and cell viability in order to understand which one can be considered as the best option in studying
T2DM using iGL cell. Spheroid was made by using the Hanging drop method. The variations of initial seeding cells were 50, 100, 200, and 400
cells/µL then incubated for 1, 2, 3, and 4 days. The evaluated parameters in this study are spheroid morphology and cell viability. Spheroid
morphology was observed by using inverted phase contrast microscope integrated with camera (Nikon) and NIS-Elements Analysis D software.
Cell viability was determined by using LUNA-II™ Automated Cell Counter (Logos Biosystem). The result of this study showed that spheroid in
all of the group cell concentration have formed since the first day and its diameter was significantly increased on the following days (p<0,05).
The spheroid size was positively correlated with the cell density in group 50-200 cells/µL. A single and stable spheroid morphology was
observed in 50-100 cells/µL group. Cell viability in 3D culture system was lower and significantly decreased since day 3 compared to 2D culture
(p <0.05; 0.01). In conclusion, spheroid derived from iGL cell line with a stable morphology and good viability could be obtained from a cell
concentration of 50-100 cells / µL with two days of incubation.
Keywords: iGL, cell density, spheroid, viability
http://repository.uhamka.ac.id/id/eprint/17282/1/Evaluation%20of%20morphology%20and%20viability%20of%20spheroid%20derived%20from%20Insulin-GLase%20cell%20line_%20A%20model%20system%20to%20understand%20Type%202%20Diabetes%20Mellitus.pdf
Unduh!
http://repository.uhamka.ac.id/id/eprint/17283/
Exercise training reduces
ventricular arrhythmias
through restoring calcium
handling and sympathetic tone
in myocardial infarction mice
Endin Nokik Stujanna, Endin
http://repository.uhamka.ac.id/id/eprint/17283/1/Exercise%20training%20reduces%20ventricular%20arrhythmias%20through%20restoring%20calcium%20handling%20and%20sympathetic%20tone%20in%20myocardial%20infarction%20mice.pdf